Let-7a Downregulation Accompanied by KRAS Mutation Is Predictive of Lung Cancer Onset in Cigarette Smoke–Exposed Mice

Background: Let-7 is a tumor suppressor microRNA targeting the KRAS lung oncogene. Let-7a downregulation is reversible during the early stages of lung carcinogenesis but is irreversible in cancer cells. The aim of this study is to shed light on the relationship between oncogene (KRAS) mutation and l...

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Detalles Bibliográficos
Autores principales: Pulliero, Alessandra, Mastracci, Luca, Tarantini, Letizia, Khalid, Zumama, Bollati, Valentina, Izzotti, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380304/
https://www.ncbi.nlm.nih.gov/pubmed/37511536
http://dx.doi.org/10.3390/ijms241411778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380304/
https://www.ncbi.nlm.nih.gov/pubmed/37511536
http://dx.doi.org/10.3390/ijms241411778

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