Perinatal S-Adenosylmethionine Supplementation Represses PSEN1 Expression by the Cellular Epigenetic Memory of CpG and Non-CpG Methylation in Adult TgCRD8 Mice

DNA methylation, the main epigenetic modification regulating gene expression, plays a role in the pathophysiology of neurodegeneration. Previous evidence indicates that 5′-flanking hypomethylation of PSEN1, a gene involved in the amyloidogenic pathway in Alzheimer’s disease (AD), boosts the AD-like...

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Detalles Bibliográficos
Autores principales: Raia, Tiziana, Armeli, Federica, Cavallaro, Rosaria A., Ferraguti, Giampiero, Businaro, Rita, Lucarelli, Marco, Fuso, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380323/
https://www.ncbi.nlm.nih.gov/pubmed/37511434
http://dx.doi.org/10.3390/ijms241411675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380323/
https://www.ncbi.nlm.nih.gov/pubmed/37511434
http://dx.doi.org/10.3390/ijms241411675

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