Cargando…

Suppression of NASH-Related HCC by Farnesyltransferase Inhibitor through Inhibition of Inflammation and Hypoxia-Inducible Factor-1α Expression

Inflammatory processes play major roles in carcinogenesis and the progression of hepatocellular carcinoma (HCC) derived from non-alcoholic steatohepatitis (NASH). But, there are no therapies for NASH-related HCC, especially focusing on these critical steps. Previous studies have reported that farnes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamada, Kohei, Tanaka, Tomokazu, Kai, Keita, Matsufuji, Shohei, Ito, Kotaro, Kitajima, Yoshihiko, Manabe, Tatsuya, Noshiro, Hirokazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380354/ https://www.ncbi.nlm.nih.gov/pubmed/37511305 http://dx.doi.org/10.3390/ijms241411546

Ejemplares similares

Matrix metalloproteinase-1 expression is regulated by HIF-1-dependent and epigenetic mechanisms and serves a tumor-suppressive role in gastric cancer progression
por: Ito, Kotaro, et al.
Publicado: (2021)

Antitumor effects of low‐dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF‐1α‐expressing gastric cancer cells
por: Egawa, Noriyuki, et al.
Publicado: (2021)

Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation
por: Okuyama, Keiichiro, et al.
Publicado: (2019)

Knockdown of hypoxia-inducible factor-1α accelerates peritoneal dissemination via the upregulation of MMP-1 expression in gastric cancer cell lines
por: HIRAKI, MASATSUGU, et al.
Publicado: (2012)

The paradox of immunotherapy in NASH-HCC
por: Peng, Yao, et al.
Publicado: (2021)

Treatment strategy for lymph node metastasis of hepatocellular carcinoma using an ICG navigation system: a case report
por: Furukawa, Shunsuke, et al.
Publicado: (2023)

Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines
por: Baba, Koichi, et al.
Publicado: (2017)

Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis
por: Wakiyama, Kota, et al.
Publicado: (2017)

Mitochondrial Dysfunction in the Transition from NASH to HCC
por: Léveillé, Mélissa, et al.
Publicado: (2019)

Farnesyltransferase inhibitors prevent HIV protease inhibitor (lopinavir/ritonavir)-induced lipodystrophy and metabolic syndrome in mice
por: Tanaka, Tomokazu, et al.
Publicado: (2018)

A case of idiopathic myointimal hyperplasia of the mesenteric veins presenting with small bowel obstruction
por: Yamada, Kohei, et al.
Publicado: (2021)

Pathogenesis from Inflammation to Cancer in NASH-Derived HCC
por: Yu, Simiao, et al.
Publicado: (2022)

CXCR2 inhibition enables NASH-HCC immunotherapy
por: Leslie, Jack, et al.
Publicado: (2022)

NASH limits anti-tumour surveillance in immunotherapy-treated HCC
por: Pfister, Dominik, et al.
Publicado: (2021)

Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
por: Dongiovanni, Paola, et al.
Publicado: (2021)

Immunohistochemical analysis of the aggregation of CD1a-positive dendritic cells in resected specimens and its association with surgical outcomes for patients with gallbladder cancer
por: Kai, Keita, et al.
Publicado: (2020)

Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC
por: Longo, Miriam, et al.
Publicado: (2021)

The Pathogenesis of HCC Driven by NASH and the Preventive and Therapeutic Effects of Natural Products
por: Shao, Gaoxuan, et al.
Publicado: (2022)

Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC
por: Boslem, Ebru, et al.
Publicado: (2023)

The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions
por: Tanaka, Tomokazu, et al.
Publicado: (2015)

Bacteria Are New Targets for Inhibitors of Human Farnesyltransferase
por: Weber, Lea, et al.
Publicado: (2021)

A Case of Multicystic Biliary Hamartoma with a Marked Peribiliary Gland Component Successfully Treated by Purely Laparoscopic Anatomical Liver Resection
por: Kai, Keita, et al.
Publicado: (2022)

Resection of NAFLD/NASH-related Hepatocellular Carcinoma (HCC): Clinical Features and Outcomes Compared with HCC Due to Other Etiologies
por: Pal Chaudhary, Surendra, et al.
Publicado: (2023)

HCC Development Is Associated to Peripheral Insulin Resistance in a Mouse Model of NASH
por: De Minicis, Samuele, et al.
Publicado: (2014)

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
por: Grohmann, Marcus, et al.
Publicado: (2018)

Altered Microbiota Diversity and Bile Acid Signaling in Cirrhotic and Noncirrhotic NASH-HCC
por: Sydor, Svenja, et al.
Publicado: (2020)

The Role of Oxidative Stress in NAFLD–NASH–HCC Transition—Focus on NADPH Oxidases
por: Gabbia, Daniela, et al.
Publicado: (2021)

Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK
por: Ge, Chenxu, et al.
Publicado: (2022)

New targets for therapy in breast cancer: Farnesyltransferase inhibitors
por: Head, Julia, et al.
Publicado: (2004)

Engineering Protein Farnesyltransferase for Enzymatic Protein Labeling Applications
por: Dozier, Jonathan K., et al.
Publicado: (2014)

Effect of farnesyltransferase inhibitor on the function of mitochondria of Plasmodium falciparum
por: Ha, Young Ran, et al.
Publicado: (2012)

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy
por: Dai, Xiaohan, et al.
Publicado: (2020)

Effect of farnesyltransferase inhibitors on SARS-CoV-2
por: Weber, Lea, et al.
Publicado: (2023)

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
por: Hagemann, Anna, et al.
Publicado: (2022)

Incidence of postoperative complications in transabdominal preperitoneal repair for groin hernia is influenced by poor performance status rather than by old age
por: Egawa, Noriyuki, et al.
Publicado: (2019)

Cytological Comparison between Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Image Analysis Software Using Touch Smear Samples of Surgically Resected Specimens
por: Kitamura, Sho, et al.
Publicado: (2022)

HIF2α Activation in NASH: A New Force Pushing Toward HCC
por: Clavería-Cabello, Alex, et al.
Publicado: (2021)

A maternal high-fat diet induces fetal origins of NASH-HCC in mice
por: Takiyama, Takao, et al.
Publicado: (2022)

Recent updates on the role of the gut-liver axis in the pathogenesis of NAFLD/NASH, HCC, and beyond
por: Ohtani, Naoko, et al.
Publicado: (2023)

Postoperative hiatal hernia after minimally invasive esophagectomy for esophageal cancer
por: Iwasaki, Hironori, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j1okd0ujrqictsrvbdbnj341a3