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Exploring the Potential of a Genome-Reduced Escherichia coli Strain for Plasmid DNA Production
The global demand for nucleic acid-based vaccines, including plasmid DNA (pDNA) and mRNA vaccines, needs efficient production platforms. However, conventional hosts for plasmid production have encountered challenges related to sequence integrity due to the presence of insertion sequences (ISs). In t...
Autores principales: | Nguyen, Thi Thuy, Bui, Le Minh, Byun, Ji-Young, Cho, Byung-Kwan, Kim, Sun Chang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380479/ https://www.ncbi.nlm.nih.gov/pubmed/37511505 http://dx.doi.org/10.3390/ijms241411749 |
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