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Inhibitor Trapping in N-Myristoyltransferases as a Mechanism for Drug Potency
Predicting inhibitor potency is critical in drug design and development, yet it has remained one of computational biology’s biggest unresolved challenges. Here, we show that in the case of the N-myristoyltransferase (NMT), this problem could be traced to the mechanisms by which the NMT enzyme is inh...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380619/ https://www.ncbi.nlm.nih.gov/pubmed/37511367 http://dx.doi.org/10.3390/ijms241411610 |