Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells

Here, we present evidence that caveolae-mediated endocytosis using LDLR is the pathway for SARS-CoV-2 virus internalization in the ocular cell line ARPE-19. Firstly, we found that, while Angiotensin-converting enzyme 2 (ACE2) is expressed in these cells, blocking ACE2 by antibody treatment did not p...

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Detalles Bibliográficos
Autores principales: Uppal, Sheetal, Postnikova, Olga, Villasmil, Rafael, Rogozin, Igor B., Bocharov, Alexander V., Eggerman, Thomas L., Poliakov, Eugenia, Redmond, T. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380832/
https://www.ncbi.nlm.nih.gov/pubmed/37511618
http://dx.doi.org/10.3390/ijms241411860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380832/
https://www.ncbi.nlm.nih.gov/pubmed/37511618
http://dx.doi.org/10.3390/ijms241411860

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