Inner Amino Acid Contacts Are Key Factors of Multistage Structural Rearrangements of DNA and Affect Substrate Specificity of Apurinic/Apyrimidinic Endonuclease APE1

Apurinic/apyrimidinic endonuclease 1 (APE1) is one of the most important enzymes in base excision repair. Studies on this enzyme have been conducted for a long time, but some aspects of its activity remain poorly understood. One such question concerns the mechanism of damaged-nucleotide recognition...

Descripción completa

Detalles Bibliográficos
Autores principales: Bulygin, Anatoly A., Syryamina, Victoria N., Kuznetsova, Aleksandra A., Novopashina, Darya S., Dzuba, Sergei A., Kuznetsov, Nikita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380840/
https://www.ncbi.nlm.nih.gov/pubmed/37511233
http://dx.doi.org/10.3390/ijms241411474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380840/
https://www.ncbi.nlm.nih.gov/pubmed/37511233
http://dx.doi.org/10.3390/ijms241411474

Ejemplares similares