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Inner Amino Acid Contacts Are Key Factors of Multistage Structural Rearrangements of DNA and Affect Substrate Specificity of Apurinic/Apyrimidinic Endonuclease APE1

Apurinic/apyrimidinic endonuclease 1 (APE1) is one of the most important enzymes in base excision repair. Studies on this enzyme have been conducted for a long time, but some aspects of its activity remain poorly understood. One such question concerns the mechanism of damaged-nucleotide recognition...

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Detalles Bibliográficos
Autores principales:	Bulygin, Anatoly A., Syryamina, Victoria N., Kuznetsova, Aleksandra A., Novopashina, Darya S., Dzuba, Sergei A., Kuznetsov, Nikita A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380840/ https://www.ncbi.nlm.nih.gov/pubmed/37511233 http://dx.doi.org/10.3390/ijms241411474

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