Cargando…
Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse
Insulin-stimulated glucose uptake in skeletal muscle is mediated by the glucose transporter GLUT4. The small GTPase Rac1 acts as a switch of signal transduction that regulates GLUT4 translocation to the plasma membrane following insulin stimulation. However, it remains obscure whether signaling casc...
Autores principales: | Chan, Man Piu, Takenaka, Nobuyuki, Satoh, Takaya |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380855/ https://www.ncbi.nlm.nih.gov/pubmed/37511290 http://dx.doi.org/10.3390/ijms241411531 |
Ejemplares similares
-
Atrophy of White Adipose Tissue Accompanied with Decreased Insulin-Stimulated Glucose Uptake in Mice Lacking the Small GTPase Rac1 Specifically in Adipocytes
por: Hasegawa, Kiko, et al.
Publicado: (2021) -
Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle
por: Takenaka, Nobuyuki, et al.
Publicado: (2019) -
Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle
por: Takenaka, Nobuyuki, et al.
Publicado: (2016) -
A Crucial Role for the Small GTPase Rac1 Downstream of the Protein Kinase Akt2 in Insulin Signaling that Regulates Glucose Uptake in Mouse Adipocytes
por: Takenaka, Nobuyuki, et al.
Publicado: (2019) -
Regulation of De Novo Lipid Synthesis by the Small GTPase Rac1 in the Adipogenic Differentiation of Progenitor Cells from Mouse White Adipose Tissue
por: Hasegawa, Kiko, et al.
Publicado: (2023)