Non-Specific Inhibition of Dipeptidyl Peptidases 8/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation

DPP4 may play a relevant role in MSC differentiation into osteoblasts or adipocytes. Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4i), such as sitagliptin and vildagliptin, are used as antidiabetic drugs. However, vildagliptin is not a specific DPP4i and also inhibits DPP8/9, which is involved in en...

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Detalles Bibliográficos
Autores principales: Torrecillas-Baena, Bárbara, Camacho-Cardenosa, Marta, Quesada-Gómez, José Manuel, Moreno-Moreno, Paloma, Dorado, Gabriel, Gálvez-Moreno, María Ángeles, Casado-Díaz, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380885/
https://www.ncbi.nlm.nih.gov/pubmed/37510747
http://dx.doi.org/10.3390/jcm12144632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380885/
https://www.ncbi.nlm.nih.gov/pubmed/37510747
http://dx.doi.org/10.3390/jcm12144632

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