The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

Osteoarthritis (OA) is progressive disease characterised by cartilage degradation, subchondral bone remodelling and inflammation of the synovium. The disease is associated with obesity, mechanical load and age. However, multiple pro-inflammatory immune mediators regulate the expression of metallopro...

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Autores principales: Kiełbowski, Kajetan, Herian, Mariola, Bakinowska, Estera, Banach, Bolesław, Sroczyński, Tomasz, Pawlik, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381003/
https://www.ncbi.nlm.nih.gov/pubmed/37511413
http://dx.doi.org/10.3390/ijms241411655
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author Kiełbowski, Kajetan
Herian, Mariola
Bakinowska, Estera
Banach, Bolesław
Sroczyński, Tomasz
Pawlik, Andrzej
author_facet Kiełbowski, Kajetan
Herian, Mariola
Bakinowska, Estera
Banach, Bolesław
Sroczyński, Tomasz
Pawlik, Andrzej
author_sort Kiełbowski, Kajetan
collection PubMed
description Osteoarthritis (OA) is progressive disease characterised by cartilage degradation, subchondral bone remodelling and inflammation of the synovium. The disease is associated with obesity, mechanical load and age. However, multiple pro-inflammatory immune mediators regulate the expression of metalloproteinases, which take part in cartilage degradation. Furthermore, genetic factors also contribute to OA susceptibility. Recent studies have highlighted that epigenetic mechanisms may regulate the expression of OA-associated genes. This review aims to present the mechanisms of OA pathogenesis and summarise current evidence regarding the role of genetics and epigenetics in this process.
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spelling pubmed-103810032023-07-29 The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis Kiełbowski, Kajetan Herian, Mariola Bakinowska, Estera Banach, Bolesław Sroczyński, Tomasz Pawlik, Andrzej Int J Mol Sci Review Osteoarthritis (OA) is progressive disease characterised by cartilage degradation, subchondral bone remodelling and inflammation of the synovium. The disease is associated with obesity, mechanical load and age. However, multiple pro-inflammatory immune mediators regulate the expression of metalloproteinases, which take part in cartilage degradation. Furthermore, genetic factors also contribute to OA susceptibility. Recent studies have highlighted that epigenetic mechanisms may regulate the expression of OA-associated genes. This review aims to present the mechanisms of OA pathogenesis and summarise current evidence regarding the role of genetics and epigenetics in this process. MDPI 2023-07-19 /pmc/articles/PMC10381003/ /pubmed/37511413 http://dx.doi.org/10.3390/ijms241411655 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kiełbowski, Kajetan
Herian, Mariola
Bakinowska, Estera
Banach, Bolesław
Sroczyński, Tomasz
Pawlik, Andrzej
The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis
title The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis
title_full The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis
title_fullStr The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis
title_full_unstemmed The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis
title_short The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis
title_sort role of genetics and epigenetic regulation in the pathogenesis of osteoarthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381003/
https://www.ncbi.nlm.nih.gov/pubmed/37511413
http://dx.doi.org/10.3390/ijms241411655
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