1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1

A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,3,4-oxadiazole or 1,3,4-thiadiazole moiety, was efficiently synthesized. The antiproliferative activity of all synthesized derivatives was evaluated against five pancreatic ductal adenoc...

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Detalles Bibliográficos
Autores principales: Carbone, Daniela, Pecoraro, Camilla, Panzeca, Giovanna, Xu, Geng, Roeten, Margot S. F., Cascioferro, Stella, Giovannetti, Elisa, Diana, Patrizia, Parrino, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381170/
https://www.ncbi.nlm.nih.gov/pubmed/37504943
http://dx.doi.org/10.3390/md21070412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381170/
https://www.ncbi.nlm.nih.gov/pubmed/37504943
http://dx.doi.org/10.3390/md21070412

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