Phosphorylation Mimetic of Myosin Regulatory Light Chain Mitigates Cardiomyopathy-Induced Myofilament Impairment in Mouse Models of RCM and DCM

This study focuses on mimicking constitutive phosphorylation in the N-terminus of the myosin regulatory light chain (S15D-RLC) as a rescue strategy for mutation-induced cardiac dysfunction in transgenic (Tg) models of restrictive (RCM) and dilated (DCM) cardiomyopathy caused by mutations in essentia...

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Detalles Bibliográficos
Autores principales: Kazmierczak, Katarzyna, Liang, Jingsheng, Maura, Luis G., Scott, Natissa K., Szczesna-Cordary, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381296/
https://www.ncbi.nlm.nih.gov/pubmed/37511838
http://dx.doi.org/10.3390/life13071463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381296/
https://www.ncbi.nlm.nih.gov/pubmed/37511838
http://dx.doi.org/10.3390/life13071463

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