Synthesis of Cystine-Stabilised Dicarba Conotoxin EpI: Ring-Closing Metathesis of Sidechain Deprotected, Sulfide-Rich Sequences

Recombinant peptide synthesis allows for large-scale production of peptides with therapeutic potential. However, access to dicarba peptidomimetics via sidechain-deprotected sequences becomes challenging with exposed Lewis basicity presented by amine and sulfur-containing residues. Presented here is...

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Detalles Bibliográficos
Autores principales: Thomson, Amy L., Robinson, Andrea J., Belgi, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381330/
https://www.ncbi.nlm.nih.gov/pubmed/37504921
http://dx.doi.org/10.3390/md21070390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381330/
https://www.ncbi.nlm.nih.gov/pubmed/37504921
http://dx.doi.org/10.3390/md21070390

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