Cargando…

Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis

Background: Liver cirrhosis is the final stage of chronic liver disease. We aimed to evaluate non-invasive scores as predictors of complications and outcome in cirrhotic patients. Methods: A total of 150 cirrhotic patients were included. Models for end-stage liver disease (MELD), albumin-bilirubin (...

Descripción completa

Detalles Bibliográficos
Autores principales: Glisic, Tijana, Popovic, Dusan D., Lolic, Iva, Toplicanin, Aleksandar, Jankovic, Katarina, Dragasevic, Sanja, Aleksic, Marko, Stjepanovic, Mihailo, Oluic, Branislav, Matovic Zaric, Vera, Radisavljevic, Mirjana M., Stojkovic Lalosevic, Milica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381513/
https://www.ncbi.nlm.nih.gov/pubmed/37510935
http://dx.doi.org/10.3390/jcm12144820
_version_ 1785080462705688576
author Glisic, Tijana
Popovic, Dusan D.
Lolic, Iva
Toplicanin, Aleksandar
Jankovic, Katarina
Dragasevic, Sanja
Aleksic, Marko
Stjepanovic, Mihailo
Oluic, Branislav
Matovic Zaric, Vera
Radisavljevic, Mirjana M.
Stojkovic Lalosevic, Milica
author_facet Glisic, Tijana
Popovic, Dusan D.
Lolic, Iva
Toplicanin, Aleksandar
Jankovic, Katarina
Dragasevic, Sanja
Aleksic, Marko
Stjepanovic, Mihailo
Oluic, Branislav
Matovic Zaric, Vera
Radisavljevic, Mirjana M.
Stojkovic Lalosevic, Milica
author_sort Glisic, Tijana
collection PubMed
description Background: Liver cirrhosis is the final stage of chronic liver disease. We aimed to evaluate non-invasive scores as predictors of complications and outcome in cirrhotic patients. Methods: A total of 150 cirrhotic patients were included. Models for end-stage liver disease (MELD), albumin-bilirubin (ALBI) score, neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MoLR), and neutrophil-lymphocyte-albumin ratio (NLA) scores were tested in relation to the development of complications and mortality using receiver operating characteristic (ROC) curves. Results: The ROC curve analysis showed (area under the curve) AUC values of NLR, NLA, ALBI, and MELD of 0.711, 0.730, 0.627, and 0.684, respectively, for short-term mortality. MELD, ALBI, and NLA scores showed a statistically significant correlation with hepatic encephalopathy (p = 0.000 vs. 0.014 vs. 0.040, respectively), and the MELD cut-off value of 16 had a sensitivity of 70% and a specificity of 52% (AUC: 0.671, 95% CI (0.577–0.765)). For the assessment of the presence of ascites, the AUC values for NLA and MoLR were 0.583 and 0.658, respectively, with cut-offs of 11.38 and 0.44. Conclusions: MELD, ALBI, and NLA are reliable predictors of hepatic encephalopathy. NLA and MoLR showed a significant correlation with the presence of ascites, and MELD, ALBI, NLR, and NLA have prognostic value to predict 30-day mortality in cirrhotic patients.
format Online
Article
Text
id pubmed-10381513
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103815132023-07-29 Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis Glisic, Tijana Popovic, Dusan D. Lolic, Iva Toplicanin, Aleksandar Jankovic, Katarina Dragasevic, Sanja Aleksic, Marko Stjepanovic, Mihailo Oluic, Branislav Matovic Zaric, Vera Radisavljevic, Mirjana M. Stojkovic Lalosevic, Milica J Clin Med Article Background: Liver cirrhosis is the final stage of chronic liver disease. We aimed to evaluate non-invasive scores as predictors of complications and outcome in cirrhotic patients. Methods: A total of 150 cirrhotic patients were included. Models for end-stage liver disease (MELD), albumin-bilirubin (ALBI) score, neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MoLR), and neutrophil-lymphocyte-albumin ratio (NLA) scores were tested in relation to the development of complications and mortality using receiver operating characteristic (ROC) curves. Results: The ROC curve analysis showed (area under the curve) AUC values of NLR, NLA, ALBI, and MELD of 0.711, 0.730, 0.627, and 0.684, respectively, for short-term mortality. MELD, ALBI, and NLA scores showed a statistically significant correlation with hepatic encephalopathy (p = 0.000 vs. 0.014 vs. 0.040, respectively), and the MELD cut-off value of 16 had a sensitivity of 70% and a specificity of 52% (AUC: 0.671, 95% CI (0.577–0.765)). For the assessment of the presence of ascites, the AUC values for NLA and MoLR were 0.583 and 0.658, respectively, with cut-offs of 11.38 and 0.44. Conclusions: MELD, ALBI, and NLA are reliable predictors of hepatic encephalopathy. NLA and MoLR showed a significant correlation with the presence of ascites, and MELD, ALBI, NLR, and NLA have prognostic value to predict 30-day mortality in cirrhotic patients. MDPI 2023-07-21 /pmc/articles/PMC10381513/ /pubmed/37510935 http://dx.doi.org/10.3390/jcm12144820 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Glisic, Tijana
Popovic, Dusan D.
Lolic, Iva
Toplicanin, Aleksandar
Jankovic, Katarina
Dragasevic, Sanja
Aleksic, Marko
Stjepanovic, Mihailo
Oluic, Branislav
Matovic Zaric, Vera
Radisavljevic, Mirjana M.
Stojkovic Lalosevic, Milica
Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis
title Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis
title_full Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis
title_fullStr Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis
title_full_unstemmed Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis
title_short Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis
title_sort hematological indices are useful in predicting complications of liver cirrhosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381513/
https://www.ncbi.nlm.nih.gov/pubmed/37510935
http://dx.doi.org/10.3390/jcm12144820
work_keys_str_mv AT glisictijana hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT popovicdusand hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT loliciva hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT toplicaninaleksandar hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT jankovickatarina hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT dragasevicsanja hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT aleksicmarko hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT stjepanovicmihailo hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT oluicbranislav hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT matoviczaricvera hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT radisavljevicmirjanam hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis
AT stojkoviclalosevicmilica hematologicalindicesareusefulinpredictingcomplicationsoflivercirrhosis