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Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis
Background: Liver cirrhosis is the final stage of chronic liver disease. We aimed to evaluate non-invasive scores as predictors of complications and outcome in cirrhotic patients. Methods: A total of 150 cirrhotic patients were included. Models for end-stage liver disease (MELD), albumin-bilirubin (...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381513/ https://www.ncbi.nlm.nih.gov/pubmed/37510935 http://dx.doi.org/10.3390/jcm12144820 |
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author | Glisic, Tijana Popovic, Dusan D. Lolic, Iva Toplicanin, Aleksandar Jankovic, Katarina Dragasevic, Sanja Aleksic, Marko Stjepanovic, Mihailo Oluic, Branislav Matovic Zaric, Vera Radisavljevic, Mirjana M. Stojkovic Lalosevic, Milica |
author_facet | Glisic, Tijana Popovic, Dusan D. Lolic, Iva Toplicanin, Aleksandar Jankovic, Katarina Dragasevic, Sanja Aleksic, Marko Stjepanovic, Mihailo Oluic, Branislav Matovic Zaric, Vera Radisavljevic, Mirjana M. Stojkovic Lalosevic, Milica |
author_sort | Glisic, Tijana |
collection | PubMed |
description | Background: Liver cirrhosis is the final stage of chronic liver disease. We aimed to evaluate non-invasive scores as predictors of complications and outcome in cirrhotic patients. Methods: A total of 150 cirrhotic patients were included. Models for end-stage liver disease (MELD), albumin-bilirubin (ALBI) score, neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MoLR), and neutrophil-lymphocyte-albumin ratio (NLA) scores were tested in relation to the development of complications and mortality using receiver operating characteristic (ROC) curves. Results: The ROC curve analysis showed (area under the curve) AUC values of NLR, NLA, ALBI, and MELD of 0.711, 0.730, 0.627, and 0.684, respectively, for short-term mortality. MELD, ALBI, and NLA scores showed a statistically significant correlation with hepatic encephalopathy (p = 0.000 vs. 0.014 vs. 0.040, respectively), and the MELD cut-off value of 16 had a sensitivity of 70% and a specificity of 52% (AUC: 0.671, 95% CI (0.577–0.765)). For the assessment of the presence of ascites, the AUC values for NLA and MoLR were 0.583 and 0.658, respectively, with cut-offs of 11.38 and 0.44. Conclusions: MELD, ALBI, and NLA are reliable predictors of hepatic encephalopathy. NLA and MoLR showed a significant correlation with the presence of ascites, and MELD, ALBI, NLR, and NLA have prognostic value to predict 30-day mortality in cirrhotic patients. |
format | Online Article Text |
id | pubmed-10381513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103815132023-07-29 Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis Glisic, Tijana Popovic, Dusan D. Lolic, Iva Toplicanin, Aleksandar Jankovic, Katarina Dragasevic, Sanja Aleksic, Marko Stjepanovic, Mihailo Oluic, Branislav Matovic Zaric, Vera Radisavljevic, Mirjana M. Stojkovic Lalosevic, Milica J Clin Med Article Background: Liver cirrhosis is the final stage of chronic liver disease. We aimed to evaluate non-invasive scores as predictors of complications and outcome in cirrhotic patients. Methods: A total of 150 cirrhotic patients were included. Models for end-stage liver disease (MELD), albumin-bilirubin (ALBI) score, neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MoLR), and neutrophil-lymphocyte-albumin ratio (NLA) scores were tested in relation to the development of complications and mortality using receiver operating characteristic (ROC) curves. Results: The ROC curve analysis showed (area under the curve) AUC values of NLR, NLA, ALBI, and MELD of 0.711, 0.730, 0.627, and 0.684, respectively, for short-term mortality. MELD, ALBI, and NLA scores showed a statistically significant correlation with hepatic encephalopathy (p = 0.000 vs. 0.014 vs. 0.040, respectively), and the MELD cut-off value of 16 had a sensitivity of 70% and a specificity of 52% (AUC: 0.671, 95% CI (0.577–0.765)). For the assessment of the presence of ascites, the AUC values for NLA and MoLR were 0.583 and 0.658, respectively, with cut-offs of 11.38 and 0.44. Conclusions: MELD, ALBI, and NLA are reliable predictors of hepatic encephalopathy. NLA and MoLR showed a significant correlation with the presence of ascites, and MELD, ALBI, NLR, and NLA have prognostic value to predict 30-day mortality in cirrhotic patients. MDPI 2023-07-21 /pmc/articles/PMC10381513/ /pubmed/37510935 http://dx.doi.org/10.3390/jcm12144820 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Glisic, Tijana Popovic, Dusan D. Lolic, Iva Toplicanin, Aleksandar Jankovic, Katarina Dragasevic, Sanja Aleksic, Marko Stjepanovic, Mihailo Oluic, Branislav Matovic Zaric, Vera Radisavljevic, Mirjana M. Stojkovic Lalosevic, Milica Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis |
title | Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis |
title_full | Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis |
title_fullStr | Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis |
title_full_unstemmed | Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis |
title_short | Hematological Indices Are Useful in Predicting Complications of Liver Cirrhosis |
title_sort | hematological indices are useful in predicting complications of liver cirrhosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381513/ https://www.ncbi.nlm.nih.gov/pubmed/37510935 http://dx.doi.org/10.3390/jcm12144820 |
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