Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review

Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflamm...

Descripción completa

Detalles Bibliográficos
Autores principales: AlSharief, Mishali, Alabdurubalnabi, Esraa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381683/
https://www.ncbi.nlm.nih.gov/pubmed/37511934
http://dx.doi.org/10.3390/life13071559
_version_ 1785080504378195968
author AlSharief, Mishali
Alabdurubalnabi, Esraa
author_facet AlSharief, Mishali
Alabdurubalnabi, Esraa
author_sort AlSharief, Mishali
collection PubMed
description Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflammation, and adverse pregnancy outcomes are no exception. As a result of periodontal pathogen invasion, a series of systemic inflammatory and immunologic events affecting the safety of the fetoplacental unit may unfold. This may be further exaggerated by physiologic hormonal and metabolic fluctuations during pregnancy. This can not only negatively affect the gestation period and consequently cause preterm low weight but also complicate the pregnancy via preeclampsia and gestational diabetes. This narrative review article aims to provide a summary of relevant available evidence pertinent to the relationship between periodontal diseases, associated periodontal pathogens and virulence mechanisms mediated by pro-inflammatory cytokines and prostaglandins, and adverse pregnancy outcomes. Furthermore, this article highlights some of the literature addressing the impact of periodontal therapy interventions and pregnancy outcomes.
format Online
Article
Text
id pubmed-10381683
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103816832023-07-29 Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review AlSharief, Mishali Alabdurubalnabi, Esraa Life (Basel) Review Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflammation, and adverse pregnancy outcomes are no exception. As a result of periodontal pathogen invasion, a series of systemic inflammatory and immunologic events affecting the safety of the fetoplacental unit may unfold. This may be further exaggerated by physiologic hormonal and metabolic fluctuations during pregnancy. This can not only negatively affect the gestation period and consequently cause preterm low weight but also complicate the pregnancy via preeclampsia and gestational diabetes. This narrative review article aims to provide a summary of relevant available evidence pertinent to the relationship between periodontal diseases, associated periodontal pathogens and virulence mechanisms mediated by pro-inflammatory cytokines and prostaglandins, and adverse pregnancy outcomes. Furthermore, this article highlights some of the literature addressing the impact of periodontal therapy interventions and pregnancy outcomes. MDPI 2023-07-13 /pmc/articles/PMC10381683/ /pubmed/37511934 http://dx.doi.org/10.3390/life13071559 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
AlSharief, Mishali
Alabdurubalnabi, Esraa
Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
title Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
title_full Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
title_fullStr Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
title_full_unstemmed Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
title_short Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
title_sort periodontal pathogens and adverse pregnancy outcomes: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381683/
https://www.ncbi.nlm.nih.gov/pubmed/37511934
http://dx.doi.org/10.3390/life13071559
work_keys_str_mv AT alshariefmishali periodontalpathogensandadversepregnancyoutcomesanarrativereview
AT alabdurubalnabiesraa periodontalpathogensandadversepregnancyoutcomesanarrativereview