Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflamm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381683/ https://www.ncbi.nlm.nih.gov/pubmed/37511934 http://dx.doi.org/10.3390/life13071559 |
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author | AlSharief, Mishali Alabdurubalnabi, Esraa |
author_facet | AlSharief, Mishali Alabdurubalnabi, Esraa |
author_sort | AlSharief, Mishali |
collection | PubMed |
description | Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflammation, and adverse pregnancy outcomes are no exception. As a result of periodontal pathogen invasion, a series of systemic inflammatory and immunologic events affecting the safety of the fetoplacental unit may unfold. This may be further exaggerated by physiologic hormonal and metabolic fluctuations during pregnancy. This can not only negatively affect the gestation period and consequently cause preterm low weight but also complicate the pregnancy via preeclampsia and gestational diabetes. This narrative review article aims to provide a summary of relevant available evidence pertinent to the relationship between periodontal diseases, associated periodontal pathogens and virulence mechanisms mediated by pro-inflammatory cytokines and prostaglandins, and adverse pregnancy outcomes. Furthermore, this article highlights some of the literature addressing the impact of periodontal therapy interventions and pregnancy outcomes. |
format | Online Article Text |
id | pubmed-10381683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103816832023-07-29 Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review AlSharief, Mishali Alabdurubalnabi, Esraa Life (Basel) Review Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflammation, and adverse pregnancy outcomes are no exception. As a result of periodontal pathogen invasion, a series of systemic inflammatory and immunologic events affecting the safety of the fetoplacental unit may unfold. This may be further exaggerated by physiologic hormonal and metabolic fluctuations during pregnancy. This can not only negatively affect the gestation period and consequently cause preterm low weight but also complicate the pregnancy via preeclampsia and gestational diabetes. This narrative review article aims to provide a summary of relevant available evidence pertinent to the relationship between periodontal diseases, associated periodontal pathogens and virulence mechanisms mediated by pro-inflammatory cytokines and prostaglandins, and adverse pregnancy outcomes. Furthermore, this article highlights some of the literature addressing the impact of periodontal therapy interventions and pregnancy outcomes. MDPI 2023-07-13 /pmc/articles/PMC10381683/ /pubmed/37511934 http://dx.doi.org/10.3390/life13071559 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review AlSharief, Mishali Alabdurubalnabi, Esraa Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
title | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
title_full | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
title_fullStr | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
title_full_unstemmed | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
title_short | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
title_sort | periodontal pathogens and adverse pregnancy outcomes: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381683/ https://www.ncbi.nlm.nih.gov/pubmed/37511934 http://dx.doi.org/10.3390/life13071559 |
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