Distinct Effects of Mitochondrial Na(+)/Ca(2+) Exchanger Inhibition and Ca(2+) Uniporter Activation on Ca(2+) Sparks and Arrhythmogenesis in Diabetic Rats

BACKGROUND: Mitochondrial dysfunction contributes to the cardiac remodeling triggered by type 2 diabetes (T2D). Mitochondrial Ca(2+) concentration ([Ca(2+)](m)) modulates the oxidative state and cytosolic Ca(2+) regulation. Thus, we investigated how T2D affects mitochondrial Ca(2+) fluxes, the downs...

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Detalles Bibliográficos
Autores principales: Velmurugan, Sathya, Liu, Ting, Chen, Kuey C., Despa, Florin, O'Rourke, Brian, Despa, Sanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382117/
https://www.ncbi.nlm.nih.gov/pubmed/37421267
http://dx.doi.org/10.1161/JAHA.123.029997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382117/
https://www.ncbi.nlm.nih.gov/pubmed/37421267
http://dx.doi.org/10.1161/JAHA.123.029997

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