CRISPR-based m(6)A modification and its potential applications in telomerase regulation

Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m(6)A epigenetic modification plays an important role in the regulation of telomerase activity. Using CRISPR epigenome editing to analyze specific m(6)A modification sites in telomerase will provide an import...

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Autores principales: Yi, Mingliang, Wang, Mingyue, Xu, Yongjie, Cao, Zhikun, Ling, Yinghui, Zhang, Zijun, Cao, Hongguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382234/
https://www.ncbi.nlm.nih.gov/pubmed/37519297
http://dx.doi.org/10.3389/fcell.2023.1200734
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author Yi, Mingliang
Wang, Mingyue
Xu, Yongjie
Cao, Zhikun
Ling, Yinghui
Zhang, Zijun
Cao, Hongguo
author_facet Yi, Mingliang
Wang, Mingyue
Xu, Yongjie
Cao, Zhikun
Ling, Yinghui
Zhang, Zijun
Cao, Hongguo
author_sort Yi, Mingliang
collection PubMed
description Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m(6)A epigenetic modification plays an important role in the regulation of telomerase activity. Using CRISPR epigenome editing to analyze specific m(6)A modification sites in telomerase will provide an important tool for analyzing the molecular mechanism of m(6)A modification regulating telomerase activity. In this review, we clarified the relevant applications of CRISPR system, paid special attention to the regulation of m(6)A modification in stem cells and cancer cells based on CRISPR system, emphasized the regulation of m(6)A modification on telomerase activity, pointed out that m(6)A modification sites regulate telomerase activity, and discussed strategies based on telomerase activity and disease treatment, which are helpful to promote the research of anti-aging and tumor related diseases.
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spelling pubmed-103822342023-07-29 CRISPR-based m(6)A modification and its potential applications in telomerase regulation Yi, Mingliang Wang, Mingyue Xu, Yongjie Cao, Zhikun Ling, Yinghui Zhang, Zijun Cao, Hongguo Front Cell Dev Biol Cell and Developmental Biology Telomerase determines cell lifespan by controlling chromosome stability and cell viability, m(6)A epigenetic modification plays an important role in the regulation of telomerase activity. Using CRISPR epigenome editing to analyze specific m(6)A modification sites in telomerase will provide an important tool for analyzing the molecular mechanism of m(6)A modification regulating telomerase activity. In this review, we clarified the relevant applications of CRISPR system, paid special attention to the regulation of m(6)A modification in stem cells and cancer cells based on CRISPR system, emphasized the regulation of m(6)A modification on telomerase activity, pointed out that m(6)A modification sites regulate telomerase activity, and discussed strategies based on telomerase activity and disease treatment, which are helpful to promote the research of anti-aging and tumor related diseases. Frontiers Media S.A. 2023-07-14 /pmc/articles/PMC10382234/ /pubmed/37519297 http://dx.doi.org/10.3389/fcell.2023.1200734 Text en Copyright © 2023 Yi, Wang, Xu, Cao, Ling, Zhang and Cao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yi, Mingliang
Wang, Mingyue
Xu, Yongjie
Cao, Zhikun
Ling, Yinghui
Zhang, Zijun
Cao, Hongguo
CRISPR-based m(6)A modification and its potential applications in telomerase regulation
title CRISPR-based m(6)A modification and its potential applications in telomerase regulation
title_full CRISPR-based m(6)A modification and its potential applications in telomerase regulation
title_fullStr CRISPR-based m(6)A modification and its potential applications in telomerase regulation
title_full_unstemmed CRISPR-based m(6)A modification and its potential applications in telomerase regulation
title_short CRISPR-based m(6)A modification and its potential applications in telomerase regulation
title_sort crispr-based m(6)a modification and its potential applications in telomerase regulation
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382234/
https://www.ncbi.nlm.nih.gov/pubmed/37519297
http://dx.doi.org/10.3389/fcell.2023.1200734
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