Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro

Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative diseases such as Alzheimer’s disease. These cells adopt distinct transcriptional subtypes known as states. Understanding state function, especially in human microglia, has been elusive owing to a lack of tools t...

Descripción completa

Detalles Bibliográficos
Autores principales: Dolan, Michael-John, Therrien, Martine, Jereb, Saša, Kamath, Tushar, Gazestani, Vahid, Atkeson, Trevor, Marsh, Samuel E., Goeva, Aleksandrina, Lojek, Neal M., Murphy, Sarah, White, Cassandra M., Joung, Julia, Liu, Bingxu, Limone, Francesco, Eggan, Kevin, Hacohen, Nir, Bernstein, Bradley E., Glass, Christopher K., Leinonen, Ville, Blurton-Jones, Mathew, Zhang, Feng, Epstein, Charles B., Macosko, Evan Z., Stevens, Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382323/
https://www.ncbi.nlm.nih.gov/pubmed/37500887
http://dx.doi.org/10.1038/s41590-023-01558-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382323/
https://www.ncbi.nlm.nih.gov/pubmed/37500887
http://dx.doi.org/10.1038/s41590-023-01558-2

Ejemplares similares