Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases

Bacterial energy metabolism has become a promising target for next-generation tuberculosis chemotherapy. One strategy to hamper ATP production is to inhibit the respiratory oxidases. The respiratory chain of Mycobacterium tuberculosis comprises a cytochrome bcc:aa(3) and a cytochrome bd ubiquinol ox...

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Detalles Bibliográficos
Autores principales: Kägi, Jan, Sloan, Willough, Schimpf, Johannes, Nasiri, Hamid R., Lashley, Dana, Friedrich, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382516/
https://www.ncbi.nlm.nih.gov/pubmed/37507428
http://dx.doi.org/10.1038/s41598-023-39430-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382516/
https://www.ncbi.nlm.nih.gov/pubmed/37507428
http://dx.doi.org/10.1038/s41598-023-39430-w

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