Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging

The conserved p38 MAPK family is activated by phosphorylation during stress responses and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune responses and blocks development when hyperactivated. Here we show that PMK-1 signaling is enhanced during early aging by modulatin...

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Detalles Bibliográficos
Autores principales: Yuan, Wang, Weaver, Yi M., Earnest, Svetlana, Taylor, Clinton A., Cobb, Melanie H., Weaver, Benjamin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382525/
https://www.ncbi.nlm.nih.gov/pubmed/37507441
http://dx.doi.org/10.1038/s41467-023-40317-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382525/
https://www.ncbi.nlm.nih.gov/pubmed/37507441
http://dx.doi.org/10.1038/s41467-023-40317-7

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