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Modulating p38 MAPK signaling by proteostasis mechanisms supports tissue integrity during growth and aging
The conserved p38 MAPK family is activated by phosphorylation during stress responses and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune responses and blocks development when hyperactivated. Here we show that PMK-1 signaling is enhanced during early aging by modulatin...
Autores principales: | Yuan, Wang, Weaver, Yi M., Earnest, Svetlana, Taylor, Clinton A., Cobb, Melanie H., Weaver, Benjamin P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382525/ https://www.ncbi.nlm.nih.gov/pubmed/37507441 http://dx.doi.org/10.1038/s41467-023-40317-7 |
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