Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage

Recent studies of severe acute inflammatory lung disease including COVID-19 identify macrophages to drive pulmonary hyperinflammation and long-term damage such as fibrosis. Here, we report on the development of a first-in-class, carbohydrate-coupled inhibitor of microRNA-21 (RCS-21), as a therapeuti...

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Detalles Bibliográficos
Autores principales: Beck, Christina, Ramanujam, Deepak, Vaccarello, Paula, Widenmeyer, Florenc, Feuerherd, Martin, Cheng, Cho-Chin, Bomhard, Anton, Abikeeva, Tatiana, Schädler, Julia, Sperhake, Jan-Peter, Graw, Matthias, Safi, Seyer, Hoffmann, Hans, Staab-Weijnitz, Claudia A., Rad, Roland, Protzer, Ulrike, Frischmuth, Thomas, Engelhardt, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382532/
https://www.ncbi.nlm.nih.gov/pubmed/37507393
http://dx.doi.org/10.1038/s41467-023-40185-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382532/
https://www.ncbi.nlm.nih.gov/pubmed/37507393
http://dx.doi.org/10.1038/s41467-023-40185-1

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