NPC1-dependent alterations in K(V)2.1–Ca(V)1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease

Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferred to the ER for distribution to other cell membranes. Muta...

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Detalles Bibliográficos
Autores principales: Casas, Maria, Murray, Karl D., Hino, Keiko, Vierra, Nicholas C., Simó, Sergi, Trimmer, James S., Dixon, Rose E., Dickson, Eamonn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382591/
https://www.ncbi.nlm.nih.gov/pubmed/37507375
http://dx.doi.org/10.1038/s41467-023-39937-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382591/
https://www.ncbi.nlm.nih.gov/pubmed/37507375
http://dx.doi.org/10.1038/s41467-023-39937-w

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