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NPC1-dependent alterations in K(V)2.1–Ca(V)1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease
Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferred to the ER for distribution to other cell membranes. Muta...
Autores principales: | Casas, Maria, Murray, Karl D., Hino, Keiko, Vierra, Nicholas C., Simó, Sergi, Trimmer, James S., Dixon, Rose E., Dickson, Eamonn J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382591/ https://www.ncbi.nlm.nih.gov/pubmed/37507375 http://dx.doi.org/10.1038/s41467-023-39937-w |
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