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Increased Central Auditory Gain and Decreased Parvalbumin-Positive Cortical Interneuron Density in the Df1/+ Mouse Model of Schizophrenia Correlate With Hearing Impairment

BACKGROUND: Hearing impairment is a risk factor for schizophrenia. Patients with 22q11.2 deletion syndrome have a 25% to 30% risk of schizophrenia, and up to 60% also have varying degrees of hearing impairment, primarily from middle-ear inflammation. The Df1/+ mouse model of 22q11.2 deletion syndrom...

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Detalles Bibliográficos
Autores principales: Zinnamon, Fhatarah A., Harrison, Freya G., Wenas, Sandra S., Liu, Qing, Wang, Kuan Hong, Linden, Jennifer F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382707/
https://www.ncbi.nlm.nih.gov/pubmed/37519460
http://dx.doi.org/10.1016/j.bpsgos.2022.03.007