An intramolecular energetic network regulates ligand recognition in a SH2 domain

In an effort to investigate the molecular determinants of ligand recognition of the C‐terminal SH2 domain of the SHP2 protein, we conducted extensive site‐directed mutagenesis and kinetic binding experiments with a peptide mimicking a specific portion of a physiological ligand (the scaffold protein...

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Detalles Bibliográficos
Autores principales: Nardella, Caterina, Pagano, Livia, Pennacchietti, Valeria, Felice, Mariana Di, Matteo, Sara Di, Diop, Awa, Malagrinò, Francesca, Marcocci, Lucia, Pietrangeli, Paola, Gianni, Stefano, Toto, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382797/
https://www.ncbi.nlm.nih.gov/pubmed/37468946
http://dx.doi.org/10.1002/pro.4729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382797/
https://www.ncbi.nlm.nih.gov/pubmed/37468946
http://dx.doi.org/10.1002/pro.4729

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