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An intramolecular energetic network regulates ligand recognition in a SH2 domain
In an effort to investigate the molecular determinants of ligand recognition of the C‐terminal SH2 domain of the SHP2 protein, we conducted extensive site‐directed mutagenesis and kinetic binding experiments with a peptide mimicking a specific portion of a physiological ligand (the scaffold protein...
Autores principales: | Nardella, Caterina, Pagano, Livia, Pennacchietti, Valeria, Felice, Mariana Di, Matteo, Sara Di, Diop, Awa, Malagrinò, Francesca, Marcocci, Lucia, Pietrangeli, Paola, Gianni, Stefano, Toto, Angelo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382797/ https://www.ncbi.nlm.nih.gov/pubmed/37468946 http://dx.doi.org/10.1002/pro.4729 |
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