Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5

Restoring functional β cell mass is a potential therapy for those with diabetes. However, the pathways regulating β cell mass are not fully understood. Previously, we demonstrated that Sox4 is required for β cell proliferation during prediabetes. Here, we report that Sox4 regulates β cell mass throu...

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Detalles Bibliográficos
Autores principales: Sasaki, Shugo, Nian, Cuilan, Xu, Eric E., Pasula, Daniel J., Winata, Helena, Grover, Sanya, Luciani, Dan S., Lynn, Francis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382860/
https://www.ncbi.nlm.nih.gov/pubmed/37520700
http://dx.doi.org/10.1016/j.isci.2023.107311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382860/
https://www.ncbi.nlm.nih.gov/pubmed/37520700
http://dx.doi.org/10.1016/j.isci.2023.107311

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