Development of an Alcohol Dilution–Lyophilization Method for the Preparation of mRNA-LNPs with Improved Storage Stability

The lipid nanoparticle (LNP) is one of the promising nanotechnologies for the delivery of RNA molecules, such as small interfering RNA (siRNA) and messenger RNA (mRNA). A series of LNPs that contain an mRNA encoding the antigen protein of SARS-CoV-2 were already approved as RNA vaccines against this...

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Detalles Bibliográficos
Autores principales: Shirane, Daiki, Tanaka, Hiroki, Sakurai, Yu, Taneichi, Sakura, Nakai, Yuta, Tange, Kota, Ishii, Itsuko, Akita, Hidetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383539/
https://www.ncbi.nlm.nih.gov/pubmed/37514007
http://dx.doi.org/10.3390/pharmaceutics15071819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383539/
https://www.ncbi.nlm.nih.gov/pubmed/37514007
http://dx.doi.org/10.3390/pharmaceutics15071819

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