Cargando…

Exploring the Molecular Targets for the Antidepressant and Antisuicidal Effects of Ketamine Enantiomers by Using Network Pharmacology and Molecular Docking

Ketamine, a racemic mixture of esketamine (S-ketamine) and arketamine (R-ketamine), has received particular attention for its rapid antidepressant and antisuicidal effects. NMDA receptor inhibition has been indicated as one of the main mechanisms of action of the racemic mixture, but other pharmacol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Altê, Glorister A., Rodrigues, Ana Lúcia S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383558/ https://www.ncbi.nlm.nih.gov/pubmed/37513925 http://dx.doi.org/10.3390/ph16071013

Ejemplares similares

Functional connectivity of the amygdala and the antidepressant and antisuicidal effects of repeated ketamine infusions in major depressive disorder
por: Liu, Haiyan, et al.
Publicado: (2023)

Antisuicidal efficacy of ketamine infusion in suicidal patients of depressive disorder
por: Pathak, Umesh, et al.
Publicado: (2021)

Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites
por: Yang, Chun, et al.
Publicado: (2019)

Exploration in the Therapeutic and Multi-Target Mechanism of Ketamine on Cerebral Ischemia Based on Network Pharmacology and Molecular Docking
por: Xiong, Li, et al.
Publicado: (2022)

Exploring the pathogenesis of depression and potential antidepressants through the integration of reverse network pharmacology, molecular docking, and molecular dynamics
por: Lu, Zhongwen, et al.
Publicado: (2023)

Association between plasma levels of BDNF and the antisuicidal effects of repeated ketamine infusions in depression with suicidal ideation
por: Zheng, Wei, et al.
Publicado: (2020)

Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
por: Bonaventura, Jordi, et al.
Publicado: (2021)

Antisuicidal (protective) factors in recovery from schizophrenia
por: Lyubov, E., et al.
Publicado: (2022)

Integration of molecular docking, molecular dynamics and network pharmacology to explore the multi‐target pharmacology of fenugreek against diabetes
por: Luo, Wenfeng, et al.
Publicado: (2023)

Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al.
por: Chen, Guang, et al.
Publicado: (2022)

Ketamine: A tale of two enantiomers
por: Jelen, Luke A, et al.
Publicado: (2020)

Exploring the Mechanism of Danshen against Myelofibrosis by Network Pharmacology and Molecular Docking
por: Li, Jie, et al.
Publicado: (2018)

Network Pharmacology and Molecular Docking to Explore the Mechanism of Kangxian Decoction for Epilepsy
por: Wang, Weitao, et al.
Publicado: (2022)

Exploring the Mechanism of Curcumin on Retinoblastoma Based on Network Pharmacology and Molecular Docking
por: Wu, Chengfu, et al.
Publicado: (2022)

Exploring the target and molecular mechanism of Astragalus membranaceus in the treatment of vascular cognitive impairment based on network pharmacology and molecular docking
por: Lin, Long, et al.
Publicado: (2023)

Exploration of the Molecular Mechanism of Polygonati Rhizoma in the Treatment of Osteoporosis Based on Network Pharmacology and Molecular Docking
por: Zhao, Jinlong, et al.
Publicado: (2022)

Integration of network pharmacology and molecular docking to explore the molecular mechanism of Cordycepin in the treatment of Alzheimer’s disease
por: Ma, Xiaoying, et al.
Publicado: (2022)

Network Pharmacology, Molecular Docking and Molecular Dynamics to Explore the Potential Immunomodulatory Mechanisms of Deer Antler
por: Liu, Lingyu, et al.
Publicado: (2023)

Is It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target?
por: Ramírez, David, et al.
Publicado: (2016)

Exploring the role of Xingren on COVID‐19 based on network pharmacology and molecular docking
por: Wang, Maoru, et al.
Publicado: (2022)

Exploring the mechanisms of neurotoxicity caused by fuzi using network pharmacology and molecular docking
por: An, Junsha, et al.
Publicado: (2022)

Exploration of the effect of Celastrol on protein targets in nasopharyngeal carcinoma: Network pharmacology, molecular docking and experimental evaluations
por: Ling, Junjun, et al.
Publicado: (2022)

Exploring the Molecular Mechanism of Qing Guang An Granule in Treating Glaucoma Using Network Pharmacology and Molecular Docking
por: Ou, Chen, et al.
Publicado: (2020)

Exploring the Mechanism of Hepatotoxicity Induced by Dictamnus dasycarpus Based on Network Pharmacology, Molecular Docking and Experimental Pharmacology
por: Gao, Peng, et al.
Publicado: (2023)

Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression
por: He, Junhui, et al.
Publicado: (2023)

Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine
por: Wohleb, Eric S., et al.
Publicado: (2017)

Exploring the Mechanism of Gyejibokryeong-hwan against Atherosclerosis Using Network Pharmacology and Molecular Docking
por: Lee, A Yeong, et al.
Publicado: (2020)

Molecular docking, network pharmacology and experimental verification to explore the mechanism of Wulongzhiyangwan in the treatment of pruritus
por: Anqi, Lyu, et al.
Publicado: (2023)

Exploring the mechanism of andrographolide in the treatment of gastric cancer through network pharmacology and molecular docking
por: Yadav, Ravi Prakash, et al.
Publicado: (2022)

Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking
por: He, Qingmin, et al.
Publicado: (2023)

Exploration of Fuzheng Yugan Mixture on COVID-19 based on network pharmacology and molecular docking
por: Jiang, Xinyu, et al.
Publicado: (2023)

Use of network pharmacology and molecular docking to explore the mechanism of action of curcuma in the treatment of osteosarcoma
por: Hu, Minhua, et al.
Publicado: (2023)

Exploration of Simiao-Yongan Decoction on knee osteoarthritis based on network pharmacology and molecular docking
por: Wang, Ying, et al.
Publicado: (2023)

Exploring the mechanism of Suanzaoren decoction in treatment of insomnia based on network pharmacology and molecular docking
por: Wang, Shuxiao, et al.
Publicado: (2023)

Exploring the mechanism of Erchen decoction in the treatment of atherosclerosis based on network pharmacology and molecular docking
por: Li, Wenwen, et al.
Publicado: (2023)

Exploration of potential targets and mechanisms of Naringenin in treating autism spectrum disorder via network pharmacology and molecular docking
por: Gai, Jialin, et al.
Publicado: (2022)

Molecular targets and mechanisms of Guanxinning tablet in treating atherosclerosis: Network pharmacology and molecular docking analysis
por: Niu, Chaofeng, et al.
Publicado: (2023)

Exploring novel targets of sitagliptin for type 2 diabetes mellitus: Network pharmacology, molecular docking, molecular dynamics simulation, and SPR approaches
por: Qi, Jian-hong, et al.
Publicado: (2023)

Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview
por: Pompili, Maurizio, et al.
Publicado: (2016)

Exploring the Molecular Mechanism of Liuwei Dihuang Pills for Treating Diabetic Nephropathy by Combined Network Pharmacology and Molecular Docking
por: Wang, Gaoxiang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kpu6kfuqt7e1o6iitigdclfdo8