Design, Synthesis, Computational and Biological Evaluation of Novel Structure Fragments Based on Lithocholic Acid (LCA)

The regulation of bile acid pathways has become a particularly promising therapeutic strategy for a variety of metabolic disorders, cancers, and diseases. However, the hydrophobicity of bile acids has been an obstacle to clinical efficacy due to off-target effects from rapid drug absorption. In this...

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Detalles Bibliográficos
Autores principales: Peng, Jiangling, Fan, Mingjie, Huang, Kelly X., Huang, Lina A., Wang, Yangmeng, Yin, Runkai, Zhao, Hanyi, Xu, Senlin, Li, Hongzhi, Agua, Alon, Xie, Jun, Horne, David A., Kandeel, Fouad, Huang, Wendong, Li, Junfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383687/
https://www.ncbi.nlm.nih.gov/pubmed/37513205
http://dx.doi.org/10.3390/molecules28145332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383687/
https://www.ncbi.nlm.nih.gov/pubmed/37513205
http://dx.doi.org/10.3390/molecules28145332

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