LSD1-Based Reversible Inhibitors Virtual Screening and Binding Mechanism Computational Study

As one of the crucial targets of epigenetics, histone lysine-specific demethylase 1 (LSD1) is significant in the occurrence and development of various tumors. Although several irreversible covalent LSD1 inhibitors have entered clinical trials, the large size and polarity of the FAD-binding pocket an...

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Detalles Bibliográficos
Autores principales: Yin, Zhili, Liu, Shaohui, Yang, Xiaoyue, Chen, Mengguo, Du, Jiangfeng, Liu, Hongmin, Yang, Longhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383809/
https://www.ncbi.nlm.nih.gov/pubmed/37513188
http://dx.doi.org/10.3390/molecules28145315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383809/
https://www.ncbi.nlm.nih.gov/pubmed/37513188
http://dx.doi.org/10.3390/molecules28145315

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