Cargando…

LSD1-Based Reversible Inhibitors Virtual Screening and Binding Mechanism Computational Study

As one of the crucial targets of epigenetics, histone lysine-specific demethylase 1 (LSD1) is significant in the occurrence and development of various tumors. Although several irreversible covalent LSD1 inhibitors have entered clinical trials, the large size and polarity of the FAD-binding pocket an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yin, Zhili, Liu, Shaohui, Yang, Xiaoyue, Chen, Mengguo, Du, Jiangfeng, Liu, Hongmin, Yang, Longhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383809/ https://www.ncbi.nlm.nih.gov/pubmed/37513188 http://dx.doi.org/10.3390/molecules28145315

Ejemplares similares

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1
por: Yang, Jie, et al.
Publicado: (2020)

Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
por: Li, Zhonghua, et al.
Publicado: (2019)

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors
por: Ma, Liying, et al.
Publicado: (2020)

Investigating the Binding Mode of Reversible LSD1 Inhibitors Derived from Stilbene Derivatives by 3D-QSAR, Molecular Docking, and Molecular Dynamics Simulation
por: Xu, Yongtao, et al.
Publicado: (2019)

Clinical activity of CC‐90011, an oral, potent, and reversible LSD1 inhibitor, in advanced malignancies
por: Hollebecque, Antoine, et al.
Publicado: (2022)

Natural products as LSD1 inhibitors for cancer therapy
por: Fang, Yuan, et al.
Publicado: (2021)

Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays
por: Liu, Yaodong, et al.
Publicado: (2022)

Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates
por: Itoh, Yukihiro, et al.
Publicado: (2014)

Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2
por: Niwa, Hideaki, et al.
Publicado: (2022)

Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease
por: Holshouser, Steven, et al.
Publicado: (2020)

Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC
por: Du, Linna, et al.
Publicado: (2023)

Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy
por: Wu, Baohong, et al.
Publicado: (2019)

Antitumor activity of LSD1 inhibitors in lung cancer
por: Mohammad, Helai P., et al.
Publicado: (2016)

Antiviral Properties of the LSD1 Inhibitor SP-2509
por: Harancher, Mitchell R., et al.
Publicado: (2020)

Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor
por: Syahdi, Rezi Riadhi, et al.
Publicado: (2012)

Inhibition of lysine-specific demethylase 1 (LSD1) prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma
por: He, Pengxing, et al.
Publicado: (2022)

GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro
por: Hong, Kyung Soo, et al.
Publicado: (2020)

Targeting LSD2 in breast cancer
por: Huang, Yi, et al.
Publicado: (2018)

The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal System: An Update
por: Malagraba, Gianluca, et al.
Publicado: (2022)

The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy
por: Liu, Huan, et al.
Publicado: (2021)

Synergistic antitumor effect of 5-fluorouracil with the novel LSD1 inhibitor ZY0511 in colorectal cancer
por: Peng, Wen, et al.
Publicado: (2020)

Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment
por: Li, Yan, et al.
Publicado: (2021)

Computational reverse chemical ecology: Virtual screening and predicting behaviorally active semiochemicals for Bactrocera dorsalis
por: P D, Kamala Jayanthi, et al.
Publicado: (2014)

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1
por: Prusevich, Polina, et al.
Publicado: (2014)

LSD1 inhibitors disrupt the GFI1 transcription repressor complex
por: Maiques-Diaz, Alba, et al.
Publicado: (2018)

Synthesis of artificial substrate based on inhibitor for detecting LSD1 activity
por: Ohta, Yuhei, et al.
Publicado: (2020)

Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer
por: Gajendran, Chandru, et al.
Publicado: (2023)

LSD: a leaf senescence database
por: Liu, Xiaochuan, et al.
Publicado: (2011)

Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer
por: Gao, Shuai, et al.
Publicado: (2020)

Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors
por: Shi, Ying, et al.
Publicado: (2018)

Sanguinarine, identified as a natural alkaloid LSD1 inhibitor, suppresses lung cancer cell growth and migration
por: Qin, Ting-ting, et al.
Publicado: (2022)

Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen
por: Shi, Tong, et al.
Publicado: (2012)

LSD1 is required for euchromatic origin firing and replication timing
por: Wang, Yue, et al.
Publicado: (2022)

Virtual Screening and Binding Analysis of Potential CD58 Inhibitors in Colorectal Cancer (CRC)
por: Guo, Rong, et al.
Publicado: (2023)

LSD: individuo y sociedad
Publicado: (1970)

Modern Clinical Research on LSD
por: Liechti, Matthias E
Publicado: (2017)

Artificial hallucination: GPT on LSD?
por: Beutel, Gernot, et al.
Publicado: (2023)

Protein DEK and DTA Aptamers: Insight Into the Interaction Mechanisms and the Computational Aptamer Design
por: Dai, Lijun, et al.
Publicado: (2022)

Binding profile of protein–ligand inhibitor complex and structure based design of new potent compounds via computer-aided virtual screening
por: Shallangwa, Gideon Adamu, et al.
Publicado: (2021)

Pharmacological Inhibition of LSD1 for Cancer Treatment
por: Yang, Guan-Jun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bi1j22tr6d1qt3gal07pk17sbc