Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?

Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research...

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Detalles Bibliográficos
Autores principales: Zhuravlev, Alexander, Cruz, Alejandro, Aksenov, Vladislav, Golovanov, Alexey, Lluch, José M., Kuhn, Hartmut, González-Lafont, Àngels, Ivanov, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383952/
https://www.ncbi.nlm.nih.gov/pubmed/37513289
http://dx.doi.org/10.3390/molecules28145418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383952/
https://www.ncbi.nlm.nih.gov/pubmed/37513289
http://dx.doi.org/10.3390/molecules28145418

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