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Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?

Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- and arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research...

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Detalles Bibliográficos
Autores principales:	Zhuravlev, Alexander, Cruz, Alejandro, Aksenov, Vladislav, Golovanov, Alexey, Lluch, José M., Kuhn, Hartmut, González-Lafont, Àngels, Ivanov, Igor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383952/ https://www.ncbi.nlm.nih.gov/pubmed/37513289 http://dx.doi.org/10.3390/molecules28145418

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