Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer

Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus investigated the toxic action of these Se agents...

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Detalles Bibliográficos
Autores principales: Fan, Teresa W.-M., Winnike, Jason, Al-Attar, Ahmad, Belshoff, Alexander C., Lorkiewicz, Pawel K., Tan, Jin Lian, Wu, Min, Higashi, Richard M., Lane, Andrew N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383978/
https://www.ncbi.nlm.nih.gov/pubmed/37512481
http://dx.doi.org/10.3390/metabo13070774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383978/
https://www.ncbi.nlm.nih.gov/pubmed/37512481
http://dx.doi.org/10.3390/metabo13070774

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