Association of CYP2C19, CYP2D6 and CYP3A4 Genetic Variants on Primaquine Hemolysis in G6PD-Deficient Patients

In the Amazon, the treatment for Plasmodium vivax is chloroquine plus primaquine. However, this regimen is limited due to the risk of acute hemolytic anemia in glucose-6-phosphate dehydrogenase deficiency. Primaquine is a prodrug that requires conversion by the CYP2D6 enzyme to be effective against...

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Detalles Bibliográficos
Autores principales: Macêdo, Marielle M., Almeida, Anne C. G., Silva, Gabrielly S., Oliveira, Amanda C., Mwangi, Victor I., Shuan, Ana C., Barbosa, Laila R. A., Rodrigues-Soares, Fernanda, Melo, Gisely C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384057/
https://www.ncbi.nlm.nih.gov/pubmed/37513742
http://dx.doi.org/10.3390/pathogens12070895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384057/
https://www.ncbi.nlm.nih.gov/pubmed/37513742
http://dx.doi.org/10.3390/pathogens12070895

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