Cargando…

LC/MS-MS Analysis of Phenolic Compounds in Hyoscyamus albus L. Extract: In Vitro Antidiabetic Activity, In Silico Molecular Docking, and In Vivo Investigation against STZ-Induced Diabetic Mice

This study aimed to investigate the chemical composition and antidiabetic properties of cultivated Hyoscyamus albus L. The ethanol extract was analyzed using LC-MS/MS, and 18 distinct phenolic compounds were identified. Among these, p-coumaric acid (6656.8 ± 3.4 µg/g), gallic acid (6516 ± 1.7 µg/g),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lekmine, Sabrina, Benslama, Ouided, Kadi, Kenza, Martín-García, Antonio Ignacio, Yilmaz, Mustafa Abdullah, Akkal, Salah, Boumegoura, Ali, Alhomida, Abdullah S., Ola, Mohammad Shamsul, Ali, Ahmad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384095/ https://www.ncbi.nlm.nih.gov/pubmed/37513927 http://dx.doi.org/10.3390/ph16071015

Ejemplares similares

Investigation of Photoprotective, Anti-Inflammatory, Antioxidant Capacities and LC–ESI–MS Phenolic Profile of Astragalus gombiformis Pomel
por: Lekmine, Sabrina, et al.
Publicado: (2021)

Ultrasound-Assisted Extraction, LC–MS/MS Analysis, Anticholinesterase, and Antioxidant Activities of Valuable Natural Metabolites from Astragalus armatus Willd.: In Silico Molecular Docking and In Vitro Enzymatic Studies
por: Lekmine, Sabrina, et al.
Publicado: (2022)

Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects
por: Karagecili, Hasan, et al.
Publicado: (2023)

Hyoscyamus
por: Evans, Hamilton
Publicado: (1888)

Investigation of the metabolic stability of olmutinib by validated LC-MS/MS: quantification in human plasma
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Sapitinib: reactive intermediates and bioactivation pathways characterized by LC-MS/MS
por: Attwa, Mohamed W., et al.
Publicado: (2019)

LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation
por: Attwa, Mohamed W, et al.
Publicado: (2021)

In-Vivo Antidiabetic Activity and In-Silico Mode of Action of LC/MS-MS Identified Flavonoids in Oleaster Leaves
por: Mechchate, Hamza, et al.
Publicado: (2020)

Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds
por: Mechchate, Hamza, et al.
Publicado: (2021)

LC-ESI-MS/MS Phenolic Profile of Volutaria lippii (L.) Cass. Extracts and Evaluation of Their In Vitro Antioxidant, Antiacetylcholinesterase, Antidiabetic, and Antibacterial Activities
por: Ben Salah, Hichem, et al.
Publicado: (2019)

Investigation of Fenebrutinib Metabolism and Bioactivation Using MS(3) Methodology in Ion Trap LC/MS
por: Alsibaee, Aishah M., et al.
Publicado: (2023)

Reactive intermediates in copanlisib metabolism identified by LC-MS/MS: phase I metabolic profiling
por: AlRabiah, Haitham, et al.
Publicado: (2019)

Identification of Iminium Intermediates Generation in the Metabolism of Tepotinib Using LC-MS/MS: In Silico and Practical Approaches to Bioactivation Pathway Elucidation
por: Abdelhameed, Ali S., et al.
Publicado: (2020)

LC-MS-Based Untargeted Metabolomics Reveals Early Biomarkers in STZ-Induced Diabetic Rats With Cognitive Impairment
por: Chen, Ruijuan, et al.
Publicado: (2021)

Reactive intermediates formation and bioactivation pathways of spebrutinib revealed by LC-MS/MS: In vitro and in silico metabolic study
por: Alsibaee, Aishah M., et al.
Publicado: (2023)

Characterization of reactive intermediates formation in dacomitinib metabolism and bioactivation pathways elucidation by LC-MS/MS: in vitro phase I metabolic investigation
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Validated LC-MS/MS Method for the Quantification of Ponatinib in Plasma: Application to Metabolic Stability
por: Kadi, Adnan A., et al.
Publicado: (2016)

Neurodegeneration in Diabetic Retina and Its Potential Drug Targets
por: Ola, Mohammad Shamsul, et al.
Publicado: (2014)

LC, MS(n) and LC–MS/MS studies for the characterization of degradation products of amlodipine
por: Tiwari, Ravi N., et al.
Publicado: (2015)

LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay
por: Attwa, Mohamed W, et al.
Publicado: (2020)

A validated LC-MS/MS analytical method for the quantification of pemigatinib: metabolic stability evaluation in human liver microsomes
por: Attwa, Mohamed W., et al.
Publicado: (2022)

Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach
por: Abdelhameed, Ali S, et al.
Publicado: (2020)

Screening of Antiglaucoma, Antidiabetic, Anti-Alzheimer, and Antioxidant Activities of Astragalus alopecurus Pall—Analysis of Phenolics Profiles by LC-MS/MS
por: Güven, Leyla, et al.
Publicado: (2023)

D-Ribose-Induced Glycation and Its Attenuation by the Aqueous Extract of Nigella sativa Seeds
por: Balyan, Prairna, et al.
Publicado: (2022)

Fecal metabolite analysis of Japanese macaques in Yakushima by LC-MS/MS and LC-QTOF-MS
por: TSUCHIDA, Sayaka, et al.
Publicado: (2021)

Validated LC-MS/MS assay for quantification of the newly approved tyrosine kinase inhibitor, dacomitinib, and application to investigating its metabolic stability
por: Abdelhameed, Ali S., et al.
Publicado: (2019)

LC-ESI-MS/MS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways
por: Kadi, Adnan A., et al.
Publicado: (2018)

Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS
por: Attwa, Mohamed W., et al.
Publicado: (2018)

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Application of LC–MS/MS in the Mycotoxins Studies
por: Gámiz-Gracia, Laura, et al.
Publicado: (2020)

A highly sensitive LC-MS/MS method to determine novel Bruton's tyrosine kinase inhibitor spebrutinib: application to metabolic stability evaluation
por: Abdelhameed, Ali S., et al.
Publicado: (2019)

Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies
por: Attwa, Mohamed W, et al.
Publicado: (2020)

Comparison of Flow Injection-MS/MS and LC-MS/MS for the Determination of Ochratoxin A
por: Zhang, Kai
Publicado: (2021)

LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol
por: Rakibe, Uday, et al.
Publicado: (2018)

Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punica granatum)—A Chemical Profiling by LC-MS/MS
por: Karagecili, Hasan, et al.
Publicado: (2023)

Evaluation of LC-MS and LC×LC-MS in analysis of zebrafish embryo samples for comprehensive lipid profiling
por: Xu, Mengmeng, et al.
Publicado: (2020)

Integrated LC-MS/MS system for plant metabolomics
por: Sawada, Yuji, et al.
Publicado: (2013)

Determination of Nine Fentanyl Drugs in Hair Samples by GC-MS/MS and LC-MS/MS
por: Wei, Qi, et al.
Publicado: (2022)

Determination of 355 Pesticides in Lemon and Lemon Juice by LC-MS/MS and GC-MS/MS
por: Aslantas, Sule, et al.
Publicado: (2023)

The Optimized Workflow for Sample Preparation in LC-MS/MS-Based Urine Proteomics
por: Saito, Suguru, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_56ecp71ba3oaema82fuil87jij