Design and Evaluation of S-Protected Thiolated-Based Itopride Hydrochloride Polymeric Nanocrystals for Functional Dyspepsia: QbD-Driven Optimization, In Situ, In Vitro, and In Vivo Investigation

Mucoadhesive nanosized crystalline aggregates (NCs) can be delivered by the gastrointestinal, nasal, or pulmonary route to improve retention at particular sites. Itopride hydrochloride (ITH) was selected as a drug candidate due to its absorption from the upper gastrointestinal tract. For drug locali...

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Detalles Bibliográficos
Autores principales: Badr, Moutaz Y., Basim, Pratap, Hosny, Khaled M., Rizg, Waleed Y., Naveen, N. Raghavendra, Kurakula, Mallesh, Alsulaimani, Fayez, Safhi, Awaji Y., Sabei, Fahad Y., Alissa, Mohammed, Alamoudi, Abdulmohsin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384278/
https://www.ncbi.nlm.nih.gov/pubmed/37513837
http://dx.doi.org/10.3390/ph16070925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384278/
https://www.ncbi.nlm.nih.gov/pubmed/37513837
http://dx.doi.org/10.3390/ph16070925

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