Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry

Phosphorodiamidate morpholinos (PMOs) are known as premier gene knockdown tools in developmental biology. PMOs are usually 25 nucleo-base-long morpholino subunits with a neutral phosphorodiamidate linkage. PMOs work via a steric blocking mechanism and are stable towards nucleases’ inside cells. PMOs...

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Detalles Bibliográficos
Autores principales: Paul, Sibasish, Caruthers, Marvin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384400/
https://www.ncbi.nlm.nih.gov/pubmed/37513252
http://dx.doi.org/10.3390/molecules28145380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384400/
https://www.ncbi.nlm.nih.gov/pubmed/37513252
http://dx.doi.org/10.3390/molecules28145380

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