Cargando…

Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry

Phosphorodiamidate morpholinos (PMOs) are known as premier gene knockdown tools in developmental biology. PMOs are usually 25 nucleo-base-long morpholino subunits with a neutral phosphorodiamidate linkage. PMOs work via a steric blocking mechanism and are stable towards nucleases’ inside cells. PMOs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paul, Sibasish, Caruthers, Marvin H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384400/ https://www.ncbi.nlm.nih.gov/pubmed/37513252 http://dx.doi.org/10.3390/molecules28145380

Ejemplares similares

Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
por: Roy, Subhadeep, et al.
Publicado: (2013)

NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks
por: Schmidtgall, Boris, et al.
Publicado: (2015)

Tandem oligonucleotide synthesis using linker phosphoramidites
por: Pon, Richard T., et al.
Publicado: (2005)

Synthesis of a Morpholino Nucleic Acid (MNA)-Uridine Phosphoramidite, and Exon Skipping Using MNA/2′-O-Methyl Mixmer Antisense Oligonucleotide
por: Chen, Suxiang, et al.
Publicado: (2016)

Synthesis of Substituted Cy5 Phosphoramidite Derivatives and Their Incorporation into Oligonucleotides Using Automated DNA Synthesis
por: Meares, Adam, et al.
Publicado: (2022)

On-demand synthesis of phosphoramidites
por: Sandahl, Alexander F., et al.
Publicado: (2021)

Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing
por: Le, Bao T., et al.
Publicado: (2022)

Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
por: Johnston, C., et al.
Publicado: (2021)

A Study on Synthesis and Upscaling of 2′-O-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis
por: Karalė, Kristina, et al.
Publicado: (2021)

Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3′-End
por: Osawa, Takashi, et al.
Publicado: (2022)

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach
por: Tsurusaki, Taiki, et al.
Publicado: (2023)

Peptide-substituted oligonucleotide synthesis and non-toxic, passive cell delivery
por: Shang, Shiying, et al.
Publicado: (2016)

Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries
por: Suchsland, Ruth, et al.
Publicado: (2018)

AMOD: a morpholino oligonucleotide selection tool
por: Klee, Eric W., et al.
Publicado: (2005)

Control of backbone chemistry and chirality boost oligonucleotide splice switching activity
por: Kandasamy, Pachamuthu, et al.
Publicado: (2022)

Development of a general methodology for labelling peptide–morpholino oligonucleotide conjugates using alkyne–azide click chemistry
por: Shabanpoor, Fazel, et al.
Publicado: (2013)

Oligonucleotide analogues with cationic backbone linkages
por: Meng, Melissa, et al.
Publicado: (2018)

Synthesis of triazole-linked morpholino oligonucleotides via Cu(I) catalysed cycloaddition
por: Palframan, Matthew J., et al.
Publicado: (2016)

Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2017)

Correction to ‘Control of backbone chemistry and chirality boost oligonucleotide splice switching activity’
Publicado: (2023)

Interplay of polyethyleneimine molecular weight and oligonucleotide backbone chemistry in the dynamics of antisense activity
por: Sundaram, Sumati, et al.
Publicado: (2007)

Morpholino antisense oligonucleotides: tools for investigating vertebrate development
por: Corey, David R, et al.
Publicado: (2001)

Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing
por: Yamazoe, Sayumi, et al.
Publicado: (2014)

Arylethynyl- or Alkynyl-Linked Pyrimidine and 7-Deazapurine 2′-Deoxyribonucleoside 3′-Phosphoramidites for Chemical Synthesis of Hypermodified Hydrophobic Oligonucleotides
por: Jestřábová, Ivana, et al.
Publicado: (2023)

A General Synthesis of C8-Arylpurine Phosphoramidites
por: Vongsutilers, Vorasit, et al.
Publicado: (2009)

Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates
por: Kupihár, Zoltán, et al.
Publicado: (2023)

Defining Synphenotype Groups in Xenopus tropicalis by Use of Antisense Morpholino Oligonucleotides
por: Rana, Amer Ahmed, et al.
Publicado: (2006)

Antisense Morpholino Oligonucleotides Reduce Neurofilament Synthesis and Inhibit Axon Regeneration in Lamprey Reticulospinal Neurons
por: Zhang, Guixin, et al.
Publicado: (2015)

A Trisbenzimidazole Phosphoramidite Building Block Enables High-Yielding Syntheses of RNA-Cleaving Oligonucleotide Conjugates
por: Zellmann, Felix, et al.
Publicado: (2020)

Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides
por: Järver, Peter, et al.
Publicado: (2015)

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2019)

Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid
por: Kim, Keunsoo, et al.
Publicado: (2014)

Micromanipulation of Gene Expression in the Adult Zebrafish Brain Using Cerebroventricular Microinjection of Morpholino Oligonucleotides
por: Kizil, Caghan, et al.
Publicado: (2013)

Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks
por: Ziemkiewicz, Kamil, et al.
Publicado: (2022)

Facile synthesis of a 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis
por: Mairhofer, Elisabeth, et al.
Publicado: (2016)

Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics
por: Maksudov, Farkhad, et al.
Publicado: (2023)

Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2018)

Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle
por: Novak, James S., et al.
Publicado: (2017)

Polyquaternium-mediated delivery of morpholino oligonucleotides for exon-skipping in vitro and in mdx mice
por: Wang, Mingxing, et al.
Publicado: (2017)

Synthesis and Structural Characterization of Stable Branched DNA G-Quadruplexes Using the Trebler Phosphoramidite
por: Ferreira, Rubén, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_jisg2d1en7buais02ceu9lv1h0