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Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure

Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are mole...

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Autores principales: Pedrosa, Lucas de Freitas, Nascimento, Karen Rebouças, Soares, Caroline Giacomelli, de Oliveira, Débora Preceliano, de Vos, Paul, Fabi, João Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384513/
https://www.ncbi.nlm.nih.gov/pubmed/37514364
http://dx.doi.org/10.3390/plants12142750
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author Pedrosa, Lucas de Freitas
Nascimento, Karen Rebouças
Soares, Caroline Giacomelli
de Oliveira, Débora Preceliano
de Vos, Paul
Fabi, João Paulo
author_facet Pedrosa, Lucas de Freitas
Nascimento, Karen Rebouças
Soares, Caroline Giacomelli
de Oliveira, Débora Preceliano
de Vos, Paul
Fabi, João Paulo
author_sort Pedrosa, Lucas de Freitas
collection PubMed
description Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are molecular weight, degree of methylation and blockiness, and monosaccharide composition. Cancer cell cytotoxicity, important fermentation-related byproducts, immunomodulation, and technological application were found in cell culture, animal models, and preclinical and clinical assessments. One of the greater extents of recent pectin technological usage involves nanoencapsulation methods for many different compounds, ranging from chemotherapy and immunotherapy to natural extracts from fruits and other sources. Structural modification (modified pectin) is also utilized to enhance the use of dietary fiber. Although pectin is already recognized as a component of significant importance, there is still a need for a comprehensive review that delves into its intricate relationships with biological effects, which depend on the source and structure of pectin. This review covers all levels of clinical research, including cell culture, animal studies, and clinical trials, to understand how the plant source and pectin structures influence the biological effects in humans and some technological applications of pectin regarding human health.
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spelling pubmed-103845132023-07-30 Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure Pedrosa, Lucas de Freitas Nascimento, Karen Rebouças Soares, Caroline Giacomelli de Oliveira, Débora Preceliano de Vos, Paul Fabi, João Paulo Plants (Basel) Review Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are molecular weight, degree of methylation and blockiness, and monosaccharide composition. Cancer cell cytotoxicity, important fermentation-related byproducts, immunomodulation, and technological application were found in cell culture, animal models, and preclinical and clinical assessments. One of the greater extents of recent pectin technological usage involves nanoencapsulation methods for many different compounds, ranging from chemotherapy and immunotherapy to natural extracts from fruits and other sources. Structural modification (modified pectin) is also utilized to enhance the use of dietary fiber. Although pectin is already recognized as a component of significant importance, there is still a need for a comprehensive review that delves into its intricate relationships with biological effects, which depend on the source and structure of pectin. This review covers all levels of clinical research, including cell culture, animal studies, and clinical trials, to understand how the plant source and pectin structures influence the biological effects in humans and some technological applications of pectin regarding human health. MDPI 2023-07-24 /pmc/articles/PMC10384513/ /pubmed/37514364 http://dx.doi.org/10.3390/plants12142750 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pedrosa, Lucas de Freitas
Nascimento, Karen Rebouças
Soares, Caroline Giacomelli
de Oliveira, Débora Preceliano
de Vos, Paul
Fabi, João Paulo
Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure
title Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure
title_full Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure
title_fullStr Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure
title_full_unstemmed Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure
title_short Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure
title_sort unveiling plant-based pectins: exploring the interplay of direct effects, fermentation, and technological applications in clinical research with a focus on the chemical structure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384513/
https://www.ncbi.nlm.nih.gov/pubmed/37514364
http://dx.doi.org/10.3390/plants12142750
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