Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF(V600E) Dual Inhibitors Endowed with Antiproliferative Activity

2,3,4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et(3)N at room temperature or in ethanol under reflux. The structures of new compounds were determined using NMR s...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., El-Sheref, Essmat M., Hassan, Alaa A., Bräse, S., Nieger, M., Youssif, Bahaa G. M., Ibrahim, Mahmoud A. A., Tawfeek, Hendawy N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384562/
https://www.ncbi.nlm.nih.gov/pubmed/37513926
http://dx.doi.org/10.3390/ph16071014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384562/
https://www.ncbi.nlm.nih.gov/pubmed/37513926
http://dx.doi.org/10.3390/ph16071014

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