Combining Molecular Dynamics Simulations and Biophysical Characterization to Investigate Protein-Specific Excipient Effects on Reteplase during Freeze Drying

We performed molecular dynamics simulations of Reteplase in the presence of different excipients to study the stabilizing mechanisms and to identify the role of excipients during freeze drying. To simulate the freeze-drying process, we divided the process into five distinct steps: (i) protein–excipi...

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Detalles Bibliográficos
Autores principales: Ko, Suk Kyu, Björkengren, Gabriella, Berner, Carolin, Winter, Gerhard, Harris, Pernille, Peters, Günther H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384596/
https://www.ncbi.nlm.nih.gov/pubmed/37514040
http://dx.doi.org/10.3390/pharmaceutics15071854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384596/
https://www.ncbi.nlm.nih.gov/pubmed/37514040
http://dx.doi.org/10.3390/pharmaceutics15071854

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