The Pleiotropic Effects of Fumarate: From Mitochondrial Respiration to Epigenetic Rewiring and DNA Repair Mechanisms

Tumor onset and its progression are strictly linked to its metabolic rewiring on the basis of the Warburg effect. In this context, fumarate emerged as a putative oncometabolite mediating cancer progression. Fumarate accumulation is usually driven by fumarate hydratase (FH) loss of function, the enzy...

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Detalles Bibliográficos
Autores principales: Giallongo, Sebastiano, Costa, Francesco, Longhitano, Lucia, Giallongo, Cesarina, Ferrigno, Jessica, Tropea, Emanuela, Vicario, Nunzio, Li Volti, Giovanni, Parenti, Rosalba, Barbagallo, Ignazio, Bramanti, Vincenzo, Tibullo, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384640/
https://www.ncbi.nlm.nih.gov/pubmed/37512586
http://dx.doi.org/10.3390/metabo13070880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384640/
https://www.ncbi.nlm.nih.gov/pubmed/37512586
http://dx.doi.org/10.3390/metabo13070880

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