Impact of Peptide Structure on Colonic Stability and Tissue Permeability

Most marketed peptide drugs are administered parenterally due to their inherent gastrointestinal (GI) instability and poor permeability across the GI epithelium. Several molecular design techniques, such as cyclisation and D-amino acid (D-AA) substitution, have been proposed to improve oral peptide...

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Detalles Bibliográficos
Autores principales: Taherali, Farhan, Chouhan, Nerisha, Wang, Fanjin, Lavielle, Sebastien, Baran, Maryana, McCoubrey, Laura E., Basit, Abdul W., Yadav, Vipul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384666/
https://www.ncbi.nlm.nih.gov/pubmed/37514143
http://dx.doi.org/10.3390/pharmaceutics15071956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384666/
https://www.ncbi.nlm.nih.gov/pubmed/37514143
http://dx.doi.org/10.3390/pharmaceutics15071956

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