A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1

HSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and brain infection. We previously reported that a trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccine provides excellent protection against vaginal HSV-1 infection in mice. He...

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Detalles Bibliográficos
Autores principales: Egan, Kevin P., Awasthi, Sita, Tebaldi, Giulia, Hook, Lauren M., Naughton, Alexis M., Fowler, Bernard T., Beattie, Mitchell, Alameh, Mohamad-Gabriel, Weissman, Drew, Cohen, Gary H., Friedman, Harvey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384700/
https://www.ncbi.nlm.nih.gov/pubmed/37515169
http://dx.doi.org/10.3390/v15071483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384700/
https://www.ncbi.nlm.nih.gov/pubmed/37515169
http://dx.doi.org/10.3390/v15071483

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