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3-Nitroindoles Serving as N-Centered Nucleophiles for Aza-1,6-Michael Addition to para-Quinone Methides

An unprecedented N-alkylation of 3-nitroindoles with para-quinone methides was developed for the first time. Using potassium carbonate as the base, a wide range of structurally diverse N-diarylmethylindole derivatives were obtained with moderated to good yields via the protection group migration/aza...

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Detalles Bibliográficos
Autores principales: Zhao, Jian-Qiang, Wang, Wen-Jie, Zhou, Shun, Xiao, Qi-Lin, Xue, Xi-Sha, Zhang, Yan-Ping, You, Yong, Wang, Zhen-Hua, Yuan, Wei-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384903/
https://www.ncbi.nlm.nih.gov/pubmed/37513401
http://dx.doi.org/10.3390/molecules28145529