Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor

Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our in-house library of pyrazolo[3,4-d]pyrimidines that are active as Src and/or Bcr-Abl TK inhibitors and performed a lead optimi...

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Detalles Bibliográficos
Autores principales: Contadini, Claudia, Cirotti, Claudia, Carbone, Anna, Norouzi, Mehrdad, Cianciusi, Annarita, Crespan, Emmanuele, Perini, Cecilia, Maga, Giovanni, Barilà, Daniela, Musumeci, Francesca, Schenone, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384936/
https://www.ncbi.nlm.nih.gov/pubmed/37513870
http://dx.doi.org/10.3390/ph16070958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384936/
https://www.ncbi.nlm.nih.gov/pubmed/37513870
http://dx.doi.org/10.3390/ph16070958

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